who.int (03.07.2025) The WHO Framework to implement a life course approach in practice summarizes current evidence to reorient health systems to produce health and well-being, draws on global examples of implementation, and proposes next steps. A life course approach acknowledges that health and well-being depend on the interaction of multiple protective and risk factors, particularly during sensitive and critical periods throughout people’s lives and across generations. It strengthens equity by recognizing how critical periods, transitions and cumulative exposures shape health trajectories. This framework targets a wide audience including governments, civil society, and other non-state actors committed to applying a life course approach and informs discussions on redesigning primary health care programmes to improve life course health trajectories.