who.int (24.07.2025) The Innovation agenda for public health in the WHO European Region 2025–2030 is a strategic blueprint developed to accelerate transformative innovation across public health systems in the Region. The Agenda responds to converging demographic, epidemiological, environmental and technological challenges that demand urgent, systemic change through innovation. It identifies four high-impact “mega shifts”, each targeting key barriers and opportunities for health innovation. These shifts prioritize mission-driven partnerships, ethical and inclusive data digital infrastructure, workforce empowerment and the realignment of incentives to ensure that public and private sector efforts are coordinated for maximum health impact, equity and sustainability. The Agenda provides actionable guidance for policy-makers, health authorities and partners, supporting the implementation of the European Programme of Work 2025–2030 and positioning the Region to achieve measurable improvements in health outcomes, system resilience and equity for all populations.